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Metabolic reprogramming in T cell senescence: a novel strategy for cancer immunotherapy

9 Apr 2025

Abstract excerpt

The complex interplay between cancer progression and immune senescence is critically influenced by metabolic reprogramming in T cells. As T cells age, especially within the tumor microenvironment, they undergo significant metabolic shifts that may hinder their proliferation and functionality. This manuscript reviews how metabolic alterations contribute to T cell senescence in cancer and discusses potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40204707
DOI: 10.1038/s41420-025-02468-y

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