Article

Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human Primates

2026-04-24

Abstract excerpt

<h4>ABSTRACT</h4> We report the discovery of novel adeno-associated virus (AAV) capsid variants engineered for superior intravitreal (IVT) gene delivery to the primate retina. Utilizing the REACH platform, we constructed a diverse AAV variant library and employed a multi-stage screening strategy involving in vitro selection on human retinal pigment cells followed by direct in vivo screening in non-human primates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be86ed76-8dfb-5258-a3a5-717bbc6ded3b
DOI: 10.64898/2026.04.23.720493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of AAV Capsids with Enhanced Intravitreal Transduction and Favorable Safety Profile in Non-Human PrimatesDOI 10.64898/2026.04.23.720493Read

In vivo–directed evolution of adeno-associated virus in the primate retinaSemantic proximity Read

AAV capsid bioengineering in primary human retinaSemantic proximity Read

In vivo directed evolution of AAV in the primate retinaSemantic proximity Read

Novel Intravitreal Retina-Targeting and Immune-Evading Adeno-Associated Virus Capsid VariantSemantic proximity Read

An adeno-associated virus variant enabling efficient ocular-directed gene delivery across speciesSemantic proximity Read

Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explantsSemantic proximity Read

Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human PrimatesSemantic proximity Read

AAV-Based Strategies for Treatment of Retinal and Choroidal Vascular Diseases: Advances in Age-Related Macular Degeneration and Diabetic Retinopathy TherapiesSemantic proximity Read

Novel Engineered AAV Variants Demonstrate Superior Blood-Brain Barrier Penetration and Safety in Non-Human PrimatesSemantic proximity Read

Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In VivoSemantic proximity Read

scAAVengr: Single-cell transcriptome-based quantification of engineered AAVs in non-human primate retinaSemantic proximity Read

Revolution of AAV in Drug Discovery: From Delivery System to Clinical ApplicationSemantic proximity Read