Article

Clinically-driven design of synthetic gene regulatory programs in human cells

2021-02-23

Abstract excerpt

Synthetic biology seeks to enable the rational design of regulatory molecules and circuits to reprogram cellular behavior. The application of this approach to human cells could lead to powerful gene and cell-based therapies that provide transformative ways to combat complex diseases. To date, however, synthetic genetic circuits are challenging to implement in clinically-relevant cell types and their components oft...

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Literature Corpus work: 9a4b81e3-af55-5495-b770-55f9d9755f87
DOI: 10.1101/2021.02.22.432371

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