Article
Generation of human embryonic stem cell models to exploit the EWSR1-CREB fusion promiscuity as a common pathway of transformation in human tumors.
Oncogene - 1 Aug 2021
Vanoli Fabio, Meskauskaite Brigita, Herviou Laurie, Mallen William, Sung Yun-Shao, Fujisawa Yumi, Zhang Lei, Simon Steven, Huangfu Danwei, Jasin Maria, Antonescu Cristina R
Abstract excerpt
Chromosomal translocations constitute driver mutations in solid tumors and leukemias. The mechanisms of how related or even identical gene fusions drive the pathogenesis of various tumor types remain elusive. One remarkable example is the presence of EWSR1 fusions with CREB1 and ATF1, members of the CREB family of transcription factors, in a variety of sarcomas, carcinomas and mesotheliomas. To address this, we...
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