Article
Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells.
Cancer research - 1 Oct 2021
Sole Anna, Grossetête Sandrine, Heintzé Maxime, Babin Loelia, Zaïdi Sakina, Revy Patrick, Renouf Benjamin, De Cian Anne, Giovannangeli Carine, Pierre-Eugène Cécile, Janoueix-Lerosey Isabelle, Couronné Lucile, Kaltenbach Sophie, Tomishima Mark, Jasin Maria, Grünewald Thomas G P, Delattre Olivier, Surdez Didier, Brunet Erika
Abstract excerpt
Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing EWSR1 with FLI1. An estimated 30% of Ewing sarcoma tumors also display genetic alterations in STAG2, TP53, or CDKN2A (SPC). Numerous attempts to develop relevant Ewing sarcoma models from primary human cells have been unsuccessful in faithfully recapitulating the phenotypic, transcriptomic, and epigenetic features of Ewing...
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