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Article

EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

Cancer research - 1 Apr 2008

Riggi Nicolò, Suvà Mario-Luca, Suvà Domizio, Cironi Luisa, Provero Paolo, Tercier Stéphane, Joseph Jean-Marc, Stehle Jean-Christophe, Baumer Karine, Kindler Vincent, Stamenkovic Ivan

Abstract excerpt

Ewing's sarcoma family tumors (ESFT) express the EWS-FLI-1 fusion gene generated by the chromosomal translocation t(11;22)(q24;q12). Expression of the EWS-FLI-1 fusion protein in a permissive cellular environment is believed to play a key role in ESFT pathogenesis. However, EWS-FLI-1 induces growth arrest or apoptosis in differentiated primary cells, and the identity of permissive primary human cells that can...

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Identifiers

PMID: 18381423
DOI: 10.1158/0008-5472.CAN-07-1761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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