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Article

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells.

Genes & development - 1 May 2010

Riggi Nicolò, Suvà Mario-Luca, De Vito Claudio, Provero Paolo, Stehle Jean-Christophe, Baumer Karine, Cironi Luisa, Janiszewska Michalina, Petricevic Tanja, Suvà Domizio, Tercier Stéphane, Joseph Jean-Marc, Guillou Louis, Stamenkovic Ivan

Abstract excerpt

Cancer stem cells (CSCs) display plasticity and self-renewal properties reminiscent of normal tissue stem cells, but the events responsible for their emergence remain obscure. We recently identified CSCs in Ewing sarcoma family tumors (ESFTs) and showed that they retain mesenchymal stem cell (MSC) plasticity. In the present study, we addressed the mechanisms that underlie ESFT CSC development. We show that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20382729
DOI: 10.1101/gad.1899710
PMCID: PMC2861191

Genes

SOX2
MSC
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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