Article

Polygenic prediction of phenotypes with a neural empirical Bayes approach

2025-07-22

Abstract excerpt

Polygenic risk scores (PRS) estimate the expected value of a phenotype based on individual genotypes. Although statistical approaches for calculating PRS have advanced considerably in recent years, few methods incorporate recently generated functional genomics atlases to improve SNP weight estimation. Here, we introduce PRS with a Functional Neural Network (PRSFNN) - a novel approach which uses a neural network in...

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Literature Corpus work: 261eda2b-aadd-50a6-9f84-38b6f49bead0
DOI: 10.1101/2025.07.21.25331918

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