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Article

Multi-scale inference of genetic trait architecture using biologically annotated neural networks.

PLoS genetics - 1 Aug 2021

Demetci Pinar, Cheng Wei, Darnell Gregory, Zhou Xiang, Ramachandran Sohini, Crawford Lorin

Abstract excerpt

In this article, we present Biologically Annotated Neural Networks (BANNs), a nonlinear probabilistic framework for association mapping in genome-wide association (GWA) studies. BANNs are feedforward models with partially connected architectures that are based on biological annotations. This setup yields a fully interpretable neural network where the input layer encodes SNP-level effects, and the hidden layer...

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Identifiers

PMID: 34411094
DOI: 10.1371/journal.pgen.1009754
PMCID: PMC8407593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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