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Article

“Minimalist” Nanovaccine Constituted from Near Whole Antigen for Cancer Immunotherapy

21 Jun 2018

Abstract excerpt

One of the major challenges in vaccine design has been the over dependence on incorporation of abundant adjuvants, which in fact is in violation of the "minimalist" principle. In the present study, a compact nanovaccine derived from a near whole antigen (up to 97 wt %) was developed. The nanovaccine structure was stabilized by free cysteines within each antigen (ovalbumin, OVA), which were tempospatially exposed...

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PMID: 29927574
DOI: 10.1021/acsnano.8b00558

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