Article
Redox-based reagents for chemoselective methionine bioconjugation.
Science (New York, N.Y.) - 10 Feb 2017
Lin Shixian, Yang Xiaoyu, Jia Shang, Weeks Amy M, Hornsby Michael, Lee Peter S, Nichiporuk Rita V, Iavarone Anthony T, Wells James A, Toste F Dean, Chang Christopher J
Abstract excerpt
Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies for applications ranging from probing protein function to antibody-drug conjugates and proteomics. In contrast, selective ligation to the other sulfur-containing amino acid, methionine, has been precluded by its intrinsically weaker nucleophilicity. Here, we report a strategy for chemoselective methionine bioconjugation...
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