Article

Targeted Ablation of Canonical Disulfide Bonds Mitigates TCR Mismatching in Engineered T Cells

2025-06-01

Abstract excerpt

T cell receptor-engineered T (TCR-T) cell therapy holds distinct advantages over chimeric antigen receptor (CAR)-T cell therapy in treating solid tumors by exploiting intracellular targets through MHC-mediated antigen presentation. Despite this potential, only one TCR-T therapy has received FDA approval to date. A key challenge lies in chain mispairing between exogenous therapeutic TCR chains and endogenous TCR ch...

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Literature Corpus work: 9fbe3f50-f8ec-517c-8f9d-a358b59fd1d4
DOI: 10.1101/2025.05.28.656745

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