Article
Enhancing Vaccine Efficacy by Engineering a Complex Synthetic Peptide To Become a Super Immunogen.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2017
Nordström Therése, Pandey Manisha, Calcutt Ainslie, Powell Jessica, Phillips Zachary N, Yeung Grace, Giddam Ashwini K, Shi Yun, Haselhorst Thomas, von Itzstein Mark, Batzloff Michael R, Good Michael F
Abstract excerpt
Peptides offer enormous promise as vaccines to prevent and protect against many infectious and noninfectious diseases. However, to date, limited vaccine efficacy has been reported and none have been licensed for human use. Innovative ways to enhance their immunogenicity are being tested, but rational sequence modification as a means to improve immune responsiveness has been neglected. Our objective was to...
Topics
- Animals
- Antibodies, Bacterial
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Carrier Proteins
- Humans
- Immunity, Humoral
- Immunization
- Mice
- Mice, Inbred BALB C
- Mutation
- Peptide Fragments
- Protein Engineering