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Article

Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells

22 Jun 2020

Abstract excerpt

Abstract The availability of MHC-binding prediction tools has been useful in guiding studies aimed at identifying candidate target Ags to generate reactive T cells and to characterize viral and tumor-reactive T cells. Nevertheless, prediction algorithms appear to function poorly for epitopes containing cysteine (Cys) residues, which can oxidize and form disulfide bonds with other Cys residues under oxidizing...

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PMID: 32571843
DOI: 10.4049/jimmunol.1901173

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