Article

Endogenous and Exogenous Electrophilic Proteome Modifications Reshape Antigen Presentation and Recognition

2025-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Cytotoxic T lymphocytes recognize infected or transformed cells through peptide antigens presented by MHC-I molecules. While peptide primary sequence canonically dictates recognition, non-enzymatic post-translational modifications (PTMs) to side chains can yield distinct epitopes that alter immune specificity. A peptide’s antigenicity is thus set by its cumulative chemical history: exposures tha...

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Literature Corpus work: 2134ecfb-763f-5cd7-b5db-16ce18c058d8
DOI: 10.1101/2025.11.06.687013

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