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Article

Rethinking the cilia hypothesis of hydrocephalus

29 Oct 2022

Abstract excerpt

Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in hydrocephalus, primarily based on observations of enlarged ventricles in mouse models of primary ciliary dyskinesia. Here, we review human and animal evidence that warrants a rethinking of the cilia hypothesis in hydrocephalus. First, we...

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PMID: 36341771
DOI: 10.1016/j.nbd.2022.105913

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