Article

Mechanistic Insights into the Substrate Egress Pathways of Human Glucose Transporters GLUT1 and GLUT9

2025-03-06

Abstract excerpt

Glucose transporters (GLUTs) play critical roles in cellular energy homeostasis and substrate-specific transport. Dysfunctional mutations can cause GLUT1 deficiency syndrome and excessive expression of GLUT1 is linked to cancer progression; while abnormal regulation of urate transport by GLUT9 is associated with hyperuricemia and gout. In this study, machine-learning driven molecular dynamics simulations have been...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6846b679-2d01-50cf-ab22-a289cd24102a
DOI: 10.1101/2025.03.04.641472

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanistic Insights into the Substrate Egress Pathways of Human Glucose Transporters GLUT1 and GLUT9DOI 10.1101/2025.03.04.641472Read

The in-silico evaluation of important GLUT9 residue for uric acid transport based on renal hypouricemia type 2.Semantic proximity Read

Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in Sugar Porter familySemantic proximity Read

Crystal structure of the human glucose transporter GLUT1.Semantic proximity Read

Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scaleSemantic proximity Read

Title: Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systemsSemantic proximity Read

Targeting the Highly Deleterious G161C and Y260C SNP Variants of the AGXT Protein Involved in Glyoxylate Metabolism Using Tauroursodeoxycholic Acid: A Computational Study.Semantic proximity Read

Glucose transporter 1 in health and diseaseSemantic proximity Read

Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced samplingSemantic proximity Read

Predicting the Three-Dimensional Structure of the Human Facilitative Glucose Transporter Glut1 by a Novel Evolutionary Homology Strategy: Insights on the Molecular Mechanism of Substrate Migration, and Binding Sites for Glucose and Inhibitory MoleculesSemantic proximity Read

Effect of the R126C mutation on the structure and function of the glucose transporter GLUT1: A molecular dynamics simulation study.Semantic proximity Read

Pathogenic mutations causing glucose transport defects in GLUT1 transporter: The role of intermolecular forces in protein structure-function.Semantic proximity Read

Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights.Semantic proximity Read