Structural basis of disease mutation and substrate recognition by the human SLC2A9 transporter.

Abstract excerpt

Urate provides ~50% of the reducing potential in human and primate plasma which is key to detoxifying reactive oxygen by-products of cellular metabolism. Urate is the endpoint of purine metabolism in primates, and its concentration in plasma is a balance between excretion from kidney and intestine, and subsequent reabsorption in and through cells of kidney proximal tubules to maintain a regulated concentration in...

Topics

• Humans
• Uric Acid
• Glucose Transport Proteins, Facilitative
• Mutation
• Hyperuricemia
• Cryoelectron Microscopy