Article

Atomic-level characterization of conformational transition and substrate binding of xCT transporter

2018-08-10

Abstract excerpt

xCT is a component of heterodimeric amino acids transporter system Xc- that has been known to work at the cross-roads of maintaining neurological processes and regulating antioxidant defense. xCT is a sodium-independent amino acid antiporter, that imports L- cystine and exports L-glutamate in a 1:1 ratio. The transporter has 12 transmembrane domains with intracellular N- and C-termini, which can undergo various co...

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Literature Corpus work: 0ce4a275-c6ed-5ff3-85d5-eb7db0a6fd95
DOI: 10.1101/389643

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