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IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired <i>Jak3</i> mutations conferring IL-7 hypersensitivity

2022-02-18

Abstract excerpt

The processes leading from disturbed B cell development to adult B cell progenitor acute lymphoblastic leukemia (BCP-ALL) are poorly understood. Here, we describe Irf4 −/− mice as prone to developing BCP-ALL with age. Irf4 −/− preB-I cells exhibited impaired differentiation but enhanced proliferation in response to IL-7, along with reduced retention in the IL-7 providing bone marrow niche due to decreased CXCL...

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Literature Corpus work
259def0a-0c59-5adc-b166-c3506c08be85
DOI
10.1101/2022.02.16.480573
Open publication

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IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired <i>Jak3</i> mutations conferring IL-7 hypersensitivityDOI 10.1101/2022.02.16.480573
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