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Article

IRF-4 functions as a tumor suppressor in early B-cell development

20 Aug 2008

Abstract excerpt

Interferon regulatory factor-4 (IRF-4) is a hematopoietic cell-restricted transcription factor important for hematopoietic development and immune response regulation. It was also originally identified as the product of a proto-oncogene involved in chromosomal translocations in multiple myeloma. In contrast to its oncogenic function in late stages of B lymphopoiesis, expression of IRF-4 is down-regulated in...

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PMID: 18713947
DOI: 10.1182/blood-2007-10-117838

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