Article
IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.
Cell death and differentiation - 1 Nov 2022
Das Gupta Dennis, Paul Christoph, Samel Nadine, Bieringer Maria, Staudenraus Daniel, Marini Federico, Raifer Hartmann, Menke Lisa, Hansal Lea, Camara Bärbel, Roth Edith, Daum Patrick, Wanzel Michael, Mernberger Marco, Nist Andrea, Bauer Uta-Maria, Helmprobst Frederik, Buchholz Malte, Roth Katrin, Bastian Lorenz, Hartmann Alina M, Baldus Claudia, Ikuta Koichi, Neubauer Andreas, Burchert Andreas, Jäck Hans-Martin, Klein Matthias, Bopp Tobias, Stiewe Thorsten, Pagenstecher Axel, Lohoff Michael
Abstract excerpt
The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4-/- mice as prone to developing BCP-ALL with age. Irf4-/- preB-I cells exhibited impaired differentiation but enhanced proliferation in response to IL-7, along with reduced retention in the IL-7 providing bone marrow niche due to decreased CXCL12...
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