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Article

An instructive role for IL7RA in the development of human B-cell precursor leukemia

2020-01-28

Abstract excerpt

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is preceded by a clinically silent pre-leukemia. Experimental models that authentically re-capitulate disease initiation and progression in human cells are lacking. We previously described activating mutations in interleukin 7 receptor alpha (IL7RA) that are associated with the poor-prognosis Philadelphia-like (Ph-like) subtype of BCP-ALL. Whether IL7RA signa...

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Identifiers and source

Literature Corpus work
761b2be7-d978-5e40-8b69-9667b0412c9e
DOI
10.1101/2020.01.27.919951
Open publication

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An instructive role for IL7RA in the development of human B-cell precursor leukemiaDOI 10.1101/2020.01.27.919951
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