Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.

doi:10.1158/2159-8290.CD-15-0892

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Article

Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.

Cancer discovery - 1 Dec 2015

Martín-Lorenzo Alberto, Hauer Julia, Vicente-Dueñas Carolina, Auer Franziska, González-Herrero Inés, García-Ramírez Idoia, Ginzel Sebastian, Thiele Ralf, Constantinescu Stefan N, Bartenhagen Christoph, Dugas Martin, Gombert Michael, Schäfer Daniel, Blanco Oscar, Mayado Andrea, Orfao Alberto, Alonso-López Diego, Rivas Javier De Las, Cobaleda César, García-Cenador Maria Begoña, García-Criado Francisco Javier, Sánchez-García Isidro, Borkhardt Arndt

Abstract excerpt

UNLABELLED: Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence supporting this hypothesis. We present in vivo genetic evidence mechanistically connecting inherited susceptibility to pB-ALL and postnatal infections by showing that pB-ALL was initiated in Pax5...

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PMID: 26408659
DOI: 10.1158/2159-8290.CD-15-0892

Genes

JAK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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