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Janus Kinase Mutations in Mice Lacking PU.1 and Spi-B Drive B Cell Leukemia through Reactive Oxygen Species-Induced DNA Damage.

Molecular and cellular biology - 28 Aug 2020

Lim Michelle, Batista Carolina R, de Oliveira Bruno R, Creighton Rachel, Ferguson Jacob, Clemmer Kurt, Knight Devon, Iansavitchous James, Mahmood Danish, Avino Mariano, DeKoter Rodney P

Abstract excerpt

Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing B cells that function as drivers for the accumulation of additional mutations in an evolutionary selection process. We investigated secondary drivers of leukemogenesis in a mouse model of B-ALL driven by PU.1/Spi-B deletion (Mb1-CreΔPB). Whole-exome-sequencing analysis revealed recurrent mutations in Jak3 (encoding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32631903
DOI: 10.1128/MCB.00189-20
PMCID: PMC7459267

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