Article

IRF4 deficiency vulnerates B progeny for leukemogenesis via Jak3 mutations resembling Ph-like B-ALL in humans

2021-03-09

Abstract excerpt

<title>Abstract</title> <p>How disturbances of B cell development provoke adult B acute lymphoblastic leukemia (B-ALL) remains poorly understood. Here we describe Irf4–/– mice as prone to developing B-ALL with age. Irf4–/– pro/preB cells exhibited impaired differentiative but enhanced proliferative potential in vitro and accumulated in spleens of healthy Irf4–/– mice, suggesting reduced adherence to the IL-7 prov...

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Literature Corpus work: 26d7d0b3-3cf6-5e69-8b10-b0b09401ce9c
DOI: 10.21203/rs.3.rs-271184/v1

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