Article

Mutant- <i>SETBP1</i> activates transcription of Myc programs to accelerate <i>CSF3R</i> -driven myeloproliferative neoplasms

2021-11-05

Abstract excerpt

Colony stimulating factor 3 receptor ( CSF3R ) mutations lead to JAK pathway activation and are the molecular hallmark of chronic neutrophilic leukemia (CNL). Approximately half of CNL patients also have mutations in SET binding protein 1 ( SETBP1) . In this study, we developed models of SETBP1 -mutant leukemia to understand the role that SETBP1 plays in CNL. SETBP1 mutations promote self-renewal of CSF3R- mu...

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Literature Corpus work: dc57a9c2-46c5-53c9-beee-4f84f4255a97
DOI: 10.1101/2021.11.04.467367

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