Article

Liver Endothelium Promotes HER3-mediated Cell Survival in <i>KRAS</i> Wild-type and Mutant Colorectal Cancer Cells

2021-04-28

Abstract excerpt

<h4>ABSTRACT</h4> We previously showed that liver endothelial cells (ECs) secreted soluble factors in a paracrine fashion and activated human epidermal growth factor receptor 3 (HER3, also known as ERBB3) for promoting colorectal cancer (CRC) growth and chemoresistance. However, RAS proteins play a critical role in receptor tyrosine kinase signaling pathways, and KRAS mutations mediate CRC resistance to therapie...

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Literature Corpus work: 258ebe82-678c-5433-9523-aa937543a65d
DOI: 10.1101/2021.04.27.441690

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