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Article

Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

Cancer cell - 11 Feb 2013

Lu Jia, Ye Xiangcang, Fan Fan, Xia Ling, Bhattacharya Rajat, Bellister Seth, Tozzi Federico, Sceusi Eric, Zhou Yunfei, Tachibana Isamu, Maru Dipen M, Hawke David H, Rak Janusz, Mani Sendurai A, Zweidler-McKay Patrick, Ellis Lee M

Abstract excerpt

We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed that, without direct cell-cell contact, ECs secrete factors that promoted the CSC phenotype in CRC cells via Notch activation. In human CRC specimens, CD133 and Notch intracellular domain-positive CRC cells colocalized in perivascular regions. An EC-derived,...

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Identifiers

PMID: 23375636
DOI: 10.1016/j.ccr.2012.12.021
PMCID: PMC3574187

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ADAM17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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