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Article

TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.

Molecular oncology - 1 Oct 2020

Navarro Rocío, Tapia-Galisteo Antonio, Martín-García Laura, Tarín Carlos, Corbacho Cesáreo, Gómez-López Gonzalo, Sánchez-Tirado Esther, Campuzano Susana, González-Cortés Araceli, Yáñez-Sedeño Paloma, Compte Marta, Álvarez-Vallina Luis, Sanz Laura

Abstract excerpt

The crosstalk between cancer cells and the tumor microenvironment has been implicated in cancer progression and metastasis. Fibroblasts and immune cells are widely known to be attracted to and modified by cancer cells. However, the role of pericytes in the tumor microenvironment beyond endothelium stabilization is poorly understood. Here, we report that pericytes promoted colorectal cancer (CRC) cell...

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Identifiers

PMID: 32767843
DOI: 10.1002/1878-0261.12779
PMCID: PMC7530788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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