Article

Liver endothelium promotes HER3-mediated cell survival in KRAS wild-type and mutant colorectal cancer cells

2021-07-26

Abstract excerpt

<title>Abstract</title> <p>We previously showed that human epidermal growth factor receptor 3 (HER3, also known as ERBB3) is a key mediator in liver endothelial cell (EC) promoting colorectal cancer (CRC) growth and chemoresistance, and suggested HER3-targeted therapy as a strategy for treating patients with metastatic CRC (mCRC) in the liver. Meanwhile, <italic>KRAS</italic> mutations occur in 40–50% of mCRC and...

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Literature Corpus work: 391d9936-7361-56d2-b8ca-e333f8854dc0
DOI: 10.21203/rs.3.rs-745208/v1

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