Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS.

Molecular cancer research : MCR - 3 Jun 2022

Rathore Moeez, Zhang Wei, Wright Michel'le, Bhattacharya Rajat, Fan Fan, Vaziri-Gohar Ali, Winter Jordan, Wang Zhenghe, Markowitz Sanford D, Willis Joseph, Ellis Lee M, Wang Rui

Abstract excerpt

We previously identified that human epidermal growth factor receptor 3 (HER3, also known as ERBB3) is a key mediator in liver endothelial cell (EC) promoting colorectal cancer growth and chemoresistance, and suggested HER3-targeted therapy as a strategy for treating patients with metastatic colorectal cancer in the liver. Meanwhile, KRAS mutations occur in 40%-50% of metastatic colorectal cancer and render...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium

Share to ErbB Receptors

Share to Mice, Nude

Share to Proto-Oncogene Proteins p21(ras)

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 35276002
DOI: 10.1158/1541-7786.MCR-21-0633
PMCID: PMC9177644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS.PMID 35276002Read ↗

Liver endothelium promotes HER3-mediated cell survival in KRAS wild-type and mutant colorectal cancer cellsSemantic proximity Read ↗

Liver Endothelium Promotes HER3-mediated Cell Survival in <i>KRAS</i> Wild-type and Mutant Colorectal Cancer CellsSemantic proximity Read ↗

LRG1 is a novel HER3 ligand and promotes growth in colorectal cancerSemantic proximity Read ↗

Co-targeting KRASG12D and the HER family is efficacious in colorectal cancer.Semantic proximity Read ↗

EphA3 promotes malignant transformation of colorectal epithelial cells by upregulating oncogenic pathways.Semantic proximity Read ↗

TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion.Semantic proximity Read ↗

Dual targeting of HER3 and EGFR in colorectal tumors might overcome anti-EGFR resistance.Semantic proximity Read ↗

PCSK9 Exhibits Novel Nuclear Localization in LSEC and Its Targeting with Bioinspired Nanoparticles Reduces Colorectal Liver MetastasisSemantic proximity Read ↗

Oncogenic ERBB3 mutations in human cancers.Semantic proximity Read ↗

Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cells.Semantic proximity Read ↗

HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signalingSemantic proximity Read ↗

Pro-tumor and prothrombotic activities of hepsin in colorectal cancer cells and suppression by venetoclaxSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.