Article

PCSK9 Exhibits Novel Nuclear Localization in LSEC and Its Targeting with Bioinspired Nanoparticles Reduces Colorectal Liver Metastasis

2026-05-29

Abstract excerpt

<h4>Background & Aims</h4> Colorectal cancer liver metastasis is the leading cause of mortality in affected patients, with liver sinusoidal endothelial cells playing a pivotal role in metastatic niche formation. Proprotein convertase subtilisin/kexin type 9 has emerged as a regulator of tumor biology, but its function in the hepatic microenvironment remains poorly defined. This study aimed to characterize the rol...

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Literature Corpus work: 821923b0-c431-5036-8dcb-5a175e955eb0
DOI: 10.64898/2026.05.26.727886

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