Article

LRG1 is a novel HER3 ligand and promotes growth in colorectal cancer

2023-11-21

Abstract excerpt

<title>Abstract</title> <p>HER3 signaling pathway plays a major role in promoting the development of metastatic colorectal cancer (mCRC). Here, we demonstrated that endothelial cells, a key component of the liver microenvironment, secrete leucine-rich alpha-2-glycoprotein 1 (LRG1) that activates HER3 as a ligand, distinct from the canonical HER3 ligand neuregulins. Blocking LRG1 in host animals either by gene kno...

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Literature Corpus work: 935e203c-6350-59b5-8d87-7ff4efacaa0b
DOI: 10.21203/rs.3.rs-3454771/v1

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