Active Participation of Membrane Lipids in Inhibition of Multidrug Transporter P-Glycoprotein

Abstract excerpt

P-glycoprotein (Pgp) is a major efflux pump in humans, overexpressed in a variety of cancers and associated with the development of multi-drug resistance. Allosteric modulation by various ligands (e.g., transport substrates, inhibitors, and ATP) has been biochemically shown to directly influence structural dynamics, and thereby, the function of Pgp. However, the molecular details of such effects, particularly with...

Topics

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• ATP Binding Cassette Transporter, Subfamily B
• ATP Binding Cassette Transporter, Subfamily G, Member 2
• Binding Sites
• Models, Molecular
• Molecular Dynamics Simulation
• Mutation
• Neoplasm Proteins
• Quinolines

Identifiers and source

Literature Corpus work

258b8d41-00ed-52a2-9f5f-6faba9f2c8c0

DOI

10.1101/2020.11.15.383794