Article

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

2025-06-24

Abstract excerpt

DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long-term changes in chromatin configuration, gene expression and DNA modifications have not been analyzed. We introduced numerous, simultaneous Cas9-...

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Literature Corpus work: 2556f2af-5b9c-5db4-b30c-8e83509c521e
DOI: 10.1101/2025.06.18.660431

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