Article

Single-Cell Multiomic Profiling Uncovers Radiation Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in Glioblastoma

2025-12-03

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) is an aggressive brain tumor that inevitably recurs after chemoradiotherapy, resulting in poor patient outcomes. Given GBM’s cellular heterogeneity, we hypothesized that radiation induces sub-population specific alterations to survive and adapt to radiation stress. We performed integrated single-cell RNA-seq and ATAC-seq analyses in Glioma Stem-Like Cultures three hours after t...

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Literature Corpus work: d64cfe7c-af1d-50db-bbde-73819b227341
DOI: 10.64898/2025.12.01.691699

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