Article

A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic Instability

2026-02-23

Abstract excerpt

Chronic low-dose ionizing radiation induces complex genomic instability encompassing both structural variants and point mutations, yet these alterations are typically analyzed as independent events, limiting detection of mechanistic coupling between rearrangement formation and localized mutagenesis at breakpoint junctions. This gap is particularly consequential given the widespread occupational and environmental e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c040b360-ac4f-5df9-b50b-fcd329187bdb
DOI: 10.64898/2026.02.21.707188

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Spatio-Temporal Analysis Framework for Characterizing Radiation-Induced Genomic InstabilityDOI 10.64898/2026.02.21.707188Read

Genomic landscape of radiation-induced somatic mutations in a normal cell.Semantic proximity Read

Process-specific somatic mutation distributions vary with three-dimensional genome structureSemantic proximity Read

Topographical archetypes of somatic mutagenesis in cancerSemantic proximity Read

A novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cellsSemantic proximity Read

Structural Variation in Cancer: Role, Prevalence, and Mechanisms.Semantic proximity Read

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesisSemantic proximity Read

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.Semantic proximity Read

Mutational impact and signature of ionizing radiationSemantic proximity Read

Distinct molecular profiles associated with early vs late genome instability in cancer.Semantic proximity Read

iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis.Semantic proximity Read

Selective and mechanistic sources of recurrent rearrangements across the cancer genomeSemantic proximity Read

Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes.Semantic proximity Read