Article

LILRB3 (ILT5) is a myeloid checkpoint on myeloid cells that elicits profound immununomodulation

2020-06-06

Abstract excerpt

Despite advances in identifying the key immunoregulatory roles of many of the human leukocyte immunoglobulin (Ig)-like receptor (LILR) family members, the function of the inhibitory molecule LILRB3 (ILT5, CD85a, LIR3) remains unclear. Studies indicate a predominant myeloid expression; however, high homology within the LILR family and a relative paucity of reagents have hindered progress for this receptor. To inves...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 254850dc-21b6-58cf-86cc-6ced4e858a4b
DOI: 10.1101/2020.06.04.135400

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LILRB3 (ILT5) is a myeloid checkpoint on myeloid cells that elicits profound immununomodulationDOI 10.1101/2020.06.04.135400Read

Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemiaSemantic proximity Read

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killingSemantic proximity Read

Integrated Pan-Cancer Analysis Reveals Distinct Clinical, Genomic and Immunological Features of the LILRB Immune Checkpoint Family in Acute Myeloid LeukemiaSemantic proximity Read

LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological NeoplasmsSemantic proximity Read

A dual positive and negative regulation of monocyte activation by leukocyte Ig-like receptor B4 depends on the position of the tyrosine residues in its ITIMs.Semantic proximity Read

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targetsSemantic proximity Read

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targetsSemantic proximity Read

Presence of LILRB4 SNP rs1048801 modulates acute myeloid leukemia progression and inhibits CD4+ T cells proliferationSemantic proximity Read

The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells.Semantic proximity Read

LAG Time in the Era of Immunotherapy—New Molecular Insights Into the Immunosuppression Mechanism of Lymphocyte Activation Gene‐3Semantic proximity Read

Modulation of Immune Cell Functions by the E3 Ligase Cbl-bSemantic proximity Read

HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.Semantic proximity Read