Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presence of LILRB4 SNP rs1048801 modulates acute myeloid leukemia progression and inhibits CD4+ T cells proliferation

25 Apr 2025

Abstract excerpt

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4), an emerging immune checkpoint molecule, exhibits therapeutic potential in acute myeloid leukemia (AML). While single nucleotide polymorphisms (SNPs) of immune checkpoint genes have been extensively investigated in AML, the association between LILRB4 genetic polymorphisms and clinical outcomes remains unexplored. We investigated SNPs within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Galectins and Cancer Biology
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40275747
DOI: 10.1093/jleuko/qiaf052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presence of LILRB4 SNP rs1048801 modulates acute myeloid leukemia progression and inhibits CD4+ T cells proliferationPMID 40275747Read ↗

Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemiaSemantic proximity Read ↗

Integrated Pan-Cancer Analysis Reveals Distinct Clinical, Genomic and Immunological Features of the LILRB Immune Checkpoint Family in Acute Myeloid LeukemiaSemantic proximity Read ↗

Immune checkpoint-related gene polymorphisms are associated with acute myeloid leukemia.Semantic proximity Read ↗

A pan-cancer landscape of LILRB4 identifies it as a context-dependent marker of the myeloid and antigen-presentation axisSemantic proximity Read ↗

CD8+T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients.Semantic proximity Read ↗

Identification of STAT4 as a biomarker associated with tumor immunity and prognosis in acute myeloid leukemiaSemantic proximity Read ↗

PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathwaySemantic proximity Read ↗

INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.Semantic proximity Read ↗

Epigenetic Silencing of Immune-Checkpoint Receptors in Bone Marrow- Infiltrating T Cells in Acute Myeloid LeukemiaSemantic proximity Read ↗

Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and RelapseSemantic proximity Read ↗

Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding.Semantic proximity Read ↗

LILRB3 (ILT5) is a myeloid checkpoint on myeloid cells that elicits profound immununomodulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.