Article
HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2011
Jones Des C, Kosmoliaptsis Vasilis, Apps Richard, Lapaque Nicolas, Smith Isobel, Kono Azumi, Chang Chiwen, Boyle Louise H, Taylor Craig J, Trowsdale John, Allen Rachel L
Abstract excerpt
Leukocyte Ig-like receptors (LILRs) are a family of innate immune receptors predominantly expressed by myeloid cells that can alter the Ag presentation properties of macrophages and dendritic cells. Several LILRs bind HLA class I. Altered LILR recognition due to HLA allelic variation could be a contributing factor in disease. We comprehensively assessed LILR binding to >90 HLA class I alleles. The inhibitory...
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