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Article

LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms

17 Dec 2022

Abstract excerpt

Leukocyte-associated immunoglobulin (Ig)-like receptor 1 (LAIR1, CD305) belongs to the family of immune-inhibitory receptors and is widely expressed on hematopoietic mature cells, particularly on immune cells. Four different types of ligands of LAIR1 have been described, including collagens, suggesting a potential immune-regulatory function on the extracellular matrix. By modulating cytokine secretion and...

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PMID: 36555775
DOI: 10.3390/ijms232416136

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