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Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia

6 Jun 2022

Abstract excerpt

Leukocyte immunoglobulin (Ig)-like receptor Bs ( LILRB s), a family of type I transmembrane glycoproteins, are known to inhibit immune activation. Here, we comprehensively evaluated the molecular, prognostic, and immunological characteristics of LILRB members in a broad spectrum of cancer types, focusing on their roles in acute myeloid leukemia (AML). We showed that LILRB s were significantly dysregulated in a...

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PMID: 35795094
DOI: 10.1016/j.omto.2022.05.011

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