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Modulation of Immune Cell Functions by the E3 Ligase Cbl-b

11 Mar 2015

Abstract excerpt

Maintenance of immunological tolerance is a critical hallmark of the immune system. Several signaling checkpoints necessary to balance activating and inhibitory input to immune cells have been described so far, among which the E3 ligase Cbl-b appears to be a central player. Cbl-b is expressed in all leukocyte subsets and regulates several signaling pathways in T cells, NK cells, B cells, and different types of...

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PMID: 25815272
DOI: 10.3389/fonc.2015.00058

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