Article

A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

2024-09-30

Abstract excerpt

Despite major successes with inhibitory receptor blockade in cancer, the identification of novel inhibitory receptors as putative drug targets is needed due to lack of durable responses, therapy resistance, and side effects. Most inhibitory receptors signal via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and previous studies estimated that our genome contains over 1600 ITIM-bearing transmembrane protei...

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Literature Corpus work: 1a5348ec-1b74-5d88-afce-f10aadbc848f
DOI: 10.7554/elife.92870.3

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