Article
The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells.
Blood - 15 Mar 2008
Young Neil T, Waller Edward C P, Patel Rashmi, Roghanian Ali, Austyn Jonathan M, Trowsdale John
Abstract excerpt
Dendritic cells (DCs) link innate and adaptive immunity, initiating and regulating effector cell responses. They ubiquitously express members of the LILR (ILT, LIR, CD85) family of molecules, some of which recognize self-HLA molecules, but little is known of their possible functions in DC biology. We demonstrate that the inhibitory receptor LILRB1 (ILT2, LIR1, CD85j) is selectively up-regulated during DC...
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