Article

Extensive binding of nebulous human transcription factors to genomic dark matter

2024-11-12

Abstract excerpt

<h4>SUMMARY</h4> The functional impact of a large portion of the human genome known as “dark matter DNA”, which is composed mainly of repeat sequences, remains enigmatic. The genome also encodes hundreds of putative and poorly characterized transcription factors (TFs). Here, we determined genomic binding locations of 166 poorly characterized human TFs in living cells. Nearly half of them associate strongly with k...

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Literature Corpus work: 1feb8385-d02b-5356-ba49-0b23e4479a99
DOI: 10.1101/2024.11.11.622123

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