Article

A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors

2017-10-19

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR-Cas9 gene editing strategies have revolutionized our ability to engineer the human genome for robust functional interrogation of complex biological processes. We have recently adapted this technology to primary human T cells to generate a high-throughput platform for analyzing the role of host factors in pathogen infection and lifecycle. Here, we describe applications of this system to in...

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Literature Corpus work: e3863cf7-c84d-56ca-a6fd-8102f0f2570d
DOI: 10.1101/205500

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