Article
Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status.
Breast cancer research : BCR - 1 Jan 2005
Zhu Yong, Brown Heather N, Zhang Yawei, Holford Theodore R, Zheng Tongzhang
Abstract excerpt
INTRODUCTION: MBD2, the gene encoding methyl-CpG-binding domain (MBD)2, is a major methylation related gene and functions as a transcriptional repressor that can specifically bind to the methylated regions of other genes. MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The present case-control study investigated associations between two single nucleotide polymorphisms...
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