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Article

SCF FBXO22 targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis

28 May 2019

Abstract excerpt

Significance Overexpression of human homologue of mouse double minute 2 (HDM2) is associated with aggressive cancer malignancy. It is therefore critical to understand cellular mechanisms for the control of HDM2 abundance. By identifying S kp1- C ullin 1- F BXO22-ROC1 (SCF FBXO22 ) as an E3 ubiquitin ligase for HDM2, our work has significantly improved knowledge of the cellular regulatory network required for the...

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PMID: 31138683
DOI: 10.1073/pnas.1820990116

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